Abstract Objective To compare the costs associated with adjunctive azithromycin compared to standard cefazolin antibiotic prophylaxis alone for unscheduled and scheduled cesarean deliveries. Methods A decision analytic model was created to compare cefazolin alone to azithromycin plus cefazolin. Conclusion Adjunctive azithromycin prophylaxis is a cost-saving strategy in both unscheduled and scheduled cesarean deliveries.
Introduction Cesarean delivery is the most common major surgical procedure performed in the United States, with over 1. Open in a separate window. Figure 1. Results Table 1 shows the baseline model inputs derived from published manuscripts, along with the ranges used for the sensitivity analyses and the data sources for each of the parameters. Figure 2. Figure 3. Footnotes Financial Disclosure The authors did not report any potential conflicts of interest. References 1. Births: Final data for National vital statistics reports.
Infectious morbidity after cesarean delivery: 10 strategies to reduce risk. Pregnancy-related mortality in the United States, — Obstetrics and gynecology. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. New England Journal of Medicine. The New England journal of medicine. Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection. American journal of obstetrics and gynecology. Decreasing incidence of postcesarean endometritis with extended-spectrum antibiotic prophylaxis. Contemporary cesarean delivery practice in the United States.
Obstetric complications, neonatal morbidity, and indications for cesarean delivery by maternal age.
Hemsell DL. Prophylactic antibiotics in gynecologic and obstetric surgery. Rev Infect Dis. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. The Cochrane database of systematic reviews. Wound infection in gynecologic surgery. Infectious diseases in obstetrics and gynecology. Health and economic impact of surgical site infections diagnosed after hospital discharge.
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Emerging infectious diseases. Cost-effectiveness of IV-to-oral switch therapy: azithromycin vs cefuroxime with or without erythromycin for the treatment of community-acquired pneumonia. A cost-minimization analysis comparing azithromycin-based and levofloxacin-based protocols for the treatment of patients hospitalized with community-acquired pneumonia: results from the CAP-IN trial.
Available from:. Prophylactic use of negative pressure wound therapy after cesarean delivery. Comparison of costs of surgical site infection and endometritis after cesarean delivery using claims and medical record data. Infection control and hospital epidemiology. Attributable costs of surgical site infection and endometritis after low transverse cesarean delivery. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. Westerman S, Wenger NK. Women and heart disease, the underrecognized burden: sex differences, biases, and unmet clinical and research challenges.
Clinical science London, England: Apr; 8 — Prophylactic antibiotics for non-laboring patients with intact membranes undergoing cesarean delivery: an economic analysis. JACC Cardiovascular imaging. Association of post-cesarean delivery endometritis with colonization of the chorioamnion by Ureaplasma urealyticum. Randomized clinical trial of extended spectrum antibiotic prophylaxis with coverage for Ureaplasma urealyticum to reduce post-cesarean delivery endometritis.
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Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surgical infections. These Zithromax tablets are typically engraved with "" on one side and "Pfizer" on the other side of the medication. Zithromax also comes in the form of mg tablets that appear similar to the mg Zithromax pills except that they are engraved with "ZTM" on one side and "Pfizer" on the other side instead. When comparing Zithromax versus amoxicillin as antibiotic choices, it is not always clear how they are different and it can be helpful to know distinguishing factors.
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Instead, it is necessary to get a prescription from a doctor or other licensed medical provider so that the Z-Pak can be dispensed by a qualified pharmacy. Push Health can connect people who might need a Z-Pack or Zithromax with a medical provider to discuss obtaining a prescription if it is safe and appropriate to do so. Side effects of a Z-Pack Zithromax include an upset stomach, nausea, dizziness, rash, and vomiting.
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