Plaquenil contains the active ingredient hydroxychloroquine sulfate mg, the antimalarial and disease-modifying antirheumatic drug DMARD used to treat malaria, rheumatoid arthritis, systemic lupus erythematosus and discoid lupus erythematosus. They also contain: calcium hydrogen phosphate, maize starch, purified water, and magnesium stearate. The film coating contains small amounts of hypromellose, macrogol , titanium dioxide, polysorbate 80, carnauba wax, black ink Tekprint SBSD , and purified water.
Plaquenil tablets mg are used to treat malaria, an infection caused by the protozoan single cell parasitic organism Plasmodium. The most common forms of plasmodium are P.
The parasite is carried by mosquitoes and is transmitted by a bite from an infected female mosquito when the first stage of the life cycle called the sporozoite is injected into the blood while the mosquito is feeding. It then migrates to the liver, where it matures into schizonts and multiplies. The next stage of the plasmodium life cycle called merozoite is released into the blood, infects red blood cells and transforms into the trophozoite that causes destruction of red blood cells.
Some merozoites transform into gametocytes and are taken up by a mosquito when feeding on blood to begin a new cycle. Symptoms of malaria, including fever, shivering, headache, vomiting, muscle pain, and joint pain, usually appear 10 to 15 days after the mosquito bite.
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However, if left untreated, malaria can quickly become life-threatening, causing anaemia and brain damage and disrupting the blood supply to vital organs. Plaquenil tablets mg contain the antimalarial hydroxychloroquine, which is active against the trophozoite stage of the plasmodium parasitic life cycle that infects red blood cells and causes their destruction. Haemoglobin, the oxygen carrying protein in blood, is released when the red blood cells are destroyed. The plasmodium parasite digests haemoglobin forming the compound haem which is toxic to cells.
Haem is converted by a parasitic enzyme to the insoluble crystalline form haemozoin that is not toxic to plasmodium. If the parasite survives in the blood due to inadequate anti-malarial treatment or lies dormant in the liver this can lead to recurrent malaria. Hydroxychloroquine in Plaquenil tablets mg are highly active against the erythrocytic forms of P.
However, they are not effective against the gametocytes of P. Plaquenil tablets mg contain hydroxychloroquine, the antimalarial and disease-modifying antirheumatic drug DMARD used to treat chronic rheumatic diseases that have an autoimmune basis when the immune system is directed against self , such as acute and chronic arthritis and mild systemic lupus erythematosus SLE and discoid lupus erythematosus DLE.
These conditions are characterised by inflammation and destruction of tissues. Rheumatoid arthritis is a chronic inflammation of the joints causing swelling, stiffness and pain and is due to inflammation of the synovial membrane, which forms a protective capsule around the joint. Systemic lupus erythematosus is characterised by the formation of autoantibodies that become deposited in various parts of the body and causes damage to the tissues and organs, including the heart, lungs, skin, joints, blood vessels, liver kidney and nervous system.
Discoid lupus erythematosus is a form of lupus erythematosus that characterised by skin lesions caused deposition of autoantibodies and chronic inflammation of the skin but is not as serious as the systemic form.
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Antimalarials like hydroxychloroquine in Plaquenil tablets mg have been found to have various immunomodulatory effects ability to influence and modify the immune system as well as antiinflamatory effects, and are classified as disease-modifying antirheumatic drug DMARD. There are several mechanisms by which hydroxychloroquine is thought to exert its beneficial effects.
These combined actions of hydroxychloroquine in Plaquenil tablets mg help slow down the progression of chronic rheumatic diseases, such as acute and chronic arthritis and mild SLE and DLE. The most commonly reported side effects when taking Plaquenil tablets mg include: abdominal pain, nausea, diarrhoea, vomiting, loss of appetite, headache, skin rash, pruritus itching , vertigo, tinnitus, nerve deafness, nervousness, dizziness hair loss, blurring of vision.
Several medications interact with Plaquenil tablets mg and should either not be taken while you are taking Plaquenil or only after discussion and instruction from your doctor:. You should take your Plaquenil tablets mg with a glass and with food of water. For rheumatoid arthritis, SLE and DLE you should take your Plaquenil tablets mg times daily for several weeks as recommended by your doctor.
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We are regulated by a number of executive government agencies in the United Kingdom including the Medicines and Healthcare products Regulatory Agency and the GPhC to ensure we offer our customers the highest level of service and peace of mind knowing that the medicines that you receive are safe, effective and authentic.
Drug prices for Plaquenil vary throughout the world with the highest prices generally in the United States. Patients can save significantly on their prescriptions drugs when purchasing them from a licensed pharmacy in the United Kingdom and other countries such as Canada, Australia, and New Zealand.
In order to offer competitive pricing, we regularly dispense parallel imported medicines. Under EU rules and regulations, which the UK is currently a part of, member states can freely move products from one state to another. Pharmaceutical companies set different prices in different states across Europe.
This means a product which sells in one state or country is often less than what it sells for in another state or country. This arbitrage allows the UK to import products from certain states in Europe at lower prices. The product which is imported requires a license from the MHRA Medicines and Healthcare products Regulatory Agency to ensure quality, safety and efficacy. In addition, the parallel imported product requires re-labelling into English Language. The repackaged medication is then offered for sale to UK citizens. Therefore, the only difference may be the packaging because some products may have different trade names in different countries, or a UK label may have been placed over the European version.
Parallel importing is standard practice in the UK. If you are unable to find your prescribed medicine on our website, please fill out the form below and we will confirm pricing and availability within 1 business day. You may also call us at and one of our patient care representatives will be happy to assist you.
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Plaquenil mg. Add to Cart. Generic Choices. Hydroxychloroquine Sulfate mg. How to Store Plaquenil Keep out of the reach and sight of children. Fast Shipping 2 to 3 weeks on average The average shipping time is 2 weeks in North America and 4 weeks internationally. Price Match Guarantee If you have been prescribed medication by your doctor and cannot afford the high price at your local pharmacy, Medix Pharmacy is the solution for you.
About Medix Pharmacy Medix Pharmacy is a fully licensed pharmacy in the United Kingdom who provides competitive pricing on brand and generic medications with international shipping. Can't find your medication? Some medications may not be listed on our website but may still be available.