Therapeutic Class. Infectious Diseases. Latest News. Local News. Medical Technology. Medical School. Search result for. Myanmar Philippines Singapore Thailand Vietnam. Australia Korea New Zealand. Concise Prescribing Info. Manufacturer Info. Full Prescribing Info. Zuellig Pharma. Azithromycin dihydrate. Penicillin is the usual drug of choice in the treatment of Streptococcus pyogenes pharyngitis, including the prophylaxis of rheumatic fever.
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Azithromycin is generally effective in the eradication of streptococci from the oropharynx; however, data establishing the efficacy of azithromycin in the subsequent prevention of rheumatic fever are not available at present. In sexually-transmitted diseases in men and women, Azithromycin is indicated in the treatment of uncomplicated genital infections due to Chlamydia trachomatis. It is also indicated in the treatment of uncomplicated genital infection due to non-multiresistant Neisseria gonorrhoeae ; concurrent infection with Treponema pallidum should be excluded.
Azithromycin is indicated, either alone or in combination with rifabutin, for prophylaxis against Mycobacterium avium-intracellulare complex MAC infection, an opportunistic infection prevalent in patients with advanced human immunodeficiency virus HIV. Zithromax IV : Azithromycin IV is indicated for the treatment of community-acquired pneumonia CAP caused by susceptible organisms, including Legionella pneumophila, in patients who require initial IV therapy.
Azithromycin IV is indicated for the treatment of pelvic inflammatory disease PID caused by susceptible organisms Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis in patients who require initial IV therapy. Zithromax: Oral azithromycin should be administered as a single daily dose. The period of dosing with regard to infection is given as follows.
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Azithromycin tablets and powder for oral suspension can be taken with or without food. Adults: For the treatment of sexually transmitted diseases caused by Chlamydia trachomatis and Haemophilus ducreyi , or susceptible Neisseria gonorrhoeae , the dose is mg as a single oral dose. Azithromycinshould be administered in combination with other antimycobacterial agents that have shown in vitro activity against MAC, such as ethambutol, at the approved dose. Children: The maximum recommended total dose for any treatment is mg for children.
Treatment for pediatric streptococcal pharyngitis should be dosed at different regimens see as follows. However, penicillin is the usual drug of choice for the treatment of Streptococcus pyogenes pharyngitis, including prophylaxis of rheumatic fever. For children weighing less than 15 kg, azithromycin suspension should be measured as closely as possible. For children weighing 15 kg or more, azithromycin suspension or as an alternative azithromycin pediatric sachets, should be administered according to the guide provided in Tables 5 and 6 see Tables 5 and 6.
Safety and efficacy for the prevention or treatment of MAC in children have not been established. Special Populations: Elderly: The same dosage as in adult patients is used in the elderly. Elderly patients may be more susceptible to the development of torsades de pointes arrhythmia than younger patients see Precautions.
Patients with Hepatic Impairment: The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment see Pharmacology: Pharmacokinetics under Actions and Precautions. IV therapy should be followed by oral azithromycin as a single daily dose of mg to complete a 7- to day course of therapy.
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The timing of the conversion to oral therapy should be done at the discretion of the physician and in accordance with clinical response. IV therapy should be followed by oral azithromycin at a single daily dose of mg to complete a 7-day course of therapy. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial anaerobic agent may be administered in combination with azithromycin. For all other indications in which the oral formulation is administered, the total dosage of mg should be given as mg daily for 3 days. As an alternative, the same total dose can be given over 5 days with mg given on Day 1, then mg daily on Days 2 to 5.
Special Populations: Children: The safety and efficacy of IV azithromycin for the treatment of infections in children have not been established. Elderly: The same dosage as in adult patients is used in the elderly. Hepatic Impairment: The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment see Precautions.
Intravenous Administration: After reconstitution and dilution, the recommended route of administration for IV azithromycin is by IV infusion only. Do not administer as an IV bolus or an intramuscular injection see Precautions and Cautions for Usage. An IV dose of mg azithromycin should be infused for a minimum duration of 1 hour.
Adverse events experienced in higher than recommended doses were similar to those seen at normal doses. In the event of overdosage, general symptomatic and supportive measures are indicated as required. The use of this product is contraindicated in patients with hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any excipient see Description.
Special Precautions. Some of these reactions with azithromycin have resulted in recurrent symptoms and required a longer period of observation and treatment. If an allergic reaction occurs, the drug should be discontinued and appropriate therapy shouldbe instituted. Physicians should be aware that reappearance of the allergic symptoms mayoccur when symptomatic therapy is discontinued.
Hepatotoxicity: Since liver is the principal route of elimination for azithromycin, the use of azithromycin should be undertaken with caution in patients with significant hepatic disease. Abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death. Discontinue azithromycin immediately if signs and symptoms of hepatitis occur. Ergot Derivatives: In patients receiving ergot derivatives, ergotism has been precipitated by co-administration of some macrolide antibiotics. There are no data concerning the possibility of an interaction between ergot and azithromycin.
However, because of the theoretical possibility of ergotism, azithromycin and ergot derivatives should not be co-administered. Superinfection: As with any antibiotic preparation, observation for signs of super infection withnon-susceptible organisms, including fungi is recommended. Clostridium difficile - Associated Diarrhea: Clostridium difficile -associated diarrhea CDAD has been reported with the use of nearly all antibacterial agents, including azithromycin, and may range in severity from mild diarrhea to fatal colitis.
Treatment with antibacterial agents alters the normal flora of the colon, leading to overgrowth of C difficile. Hypertoxin-producing strains of C difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use.
Careful medical history is necessary since CDAD has been reported to occur over 2 months after the administration of antibacterial agents. Due to the sucrose content 3. Prolongation of the QT interval: Prolonged cardiac repolarization and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been seen in treatment with macrolides, including azithromycin see Adverse Reactions.
Prescribers should consider the risk of QT prolongation, which can be fatal when weighing the risks and benefits of azithromycin for at-risk groups including: Patients with congenital or documented QT prolongation; patients currently receiving treatment with other active substances known to prolong QTinterval, such as antiarrhythmics of Classes IA and III, antipsychotic agents, antidepressants, and fluoroquinolones; patients with electrolyte disturbance, particularly in cases of hypokalemia and hypomagnesemia; patients with clinically relevant bradycardia, cardiac arrhythmia or cardiac insufficiency.
Elderly Patients: Elderly patients may be more susceptible to drug-associated effects on the QT interval. Intravenous Administration: Azithromycin for injection should be reconstituted and diluted as directed and administered as an IV infusion over not less than 60 minutes. Effects on the Ability to Drive or Use Machines: There is no evidence to suggest that azithromycin may have an effect on a patient's ability to drive or operate machinery.
Fertility: In fertility studies conducted in rats, reduced pregnancy rates were noted following administration of azithromycin. The relevance of this finding to humans is unknown. Use in Pregnancy: Animal reproduction studies have been performed at doses up to moderately maternally toxic dose concentrations. In these studies, no evidence of harm to the fetus due to azithromycin was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, azithromycin should be used during pregnancy only if clearly needed.
Use in Lactation: Azithromycin has been reported to be secreted into human breast milk, but there are no adequate and well-controlled clinical studies in nursing women that have characterized the pharmacokinetics of azithromycin excretion into human breast milk. New York is the hardest-hit state in the U.
During a news conference on Sunday, Cuomo announced that the state has acquired 70, doses of hydroxychloroquine, 10, doses of zithromax and , doses of chloroquine. The trials will start Tuesday, he said. Hydroxychloroquine and chloroquine are antimalarial drugs. Zithromax, or azithromycin, is an antibiotic. I have spoken with a number of health officials and there is a good basis to believe that they could work. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
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Please refer to this study by its ClinicalTrials. More Information.
Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. Clin Infect Dis. Biswas S. In-vitro antimalarial activity of azithromycin against chloroquine sensitive and chloroquine resistant Plasmodium falciparum.